Fig. 1From: SDF1–CXCR4 signaling contributes to persistent pain and hypersensitivity via regulating excitability of primary nociceptive neurons: involvement of ERK-dependent Nav1.8 up-regulationLocalization of CXCR4 in rat primary nociceptive neurons. Immunofluorescence micrographs show the double-staining of CXCR4 (a–c) with IB4 (a1), substance P (SP, b1), and TRPV1 (c1). Showing merged images from a1 and a2, b1 and b2, c1 and c2. Note that CXCR4 was co-localized with IB4, SP, and TRPV1 in subpopulations of DRG neurons (a2–c2)Back to article page