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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: SDF1–CXCR4 signaling contributes to persistent pain and hypersensitivity via regulating excitability of primary nociceptive neurons: involvement of ERK-dependent Nav1.8 up-regulation

Fig. 2

Intraplantar BV injection induces up-regulation of SDF1 and CXCR4 in the rat lumbar DRG. a Representative immunofluorescence photomicrographs of SDF1 in lumbar DRG from saline-treated rats and BV-treated rats. b Quantification of the mean immunofluorescent intensity of SDF1 showing an increase in SDF1 expression following intraplantar BV injection (n = 5/group, ***P < 0.001). c Immunofluorescent photomicrographs of double-staining of the SDF1 (red) with GFAP (green), a marker for satellite glial cell. d Representative immunofluorescent photomicrographs of CXCR4 in the lumbar DRG from saline-treated rats, BV-treated rats, and rats that received AMD3100 10 min before BV injection. e Quantification of the mean immunofluorescent intensity of CXCR4 showing an increase in CXCR4 expression following intraplantar BV injection and a reduction of CXCR4 in rats that received AMD3100 10 min before injection (n = 5/group, ***P < 0.001). f Western blot showing the expression of CXCR4 in lumbar DRG from saline-treated rats, BV-treated rats, and rats that received AMD3100 10 min before BV injection. Representative bands are shown on the top, and data summary is shown on the bottom. (n = 3/group, **P < 0.01, ***P < 0.001)

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Journal of Neuroinflammation

ISSN: 1742-2094