Fig. 3

Reversal of BV-induced hyperexcitability of small- and medium-sized DRG neurons by antagonism of CXCR4. a Representative traces of current-evoked action potentials (AP) in the DRG neurons harvested from saline-treated and BV-treated rats. b–e Histograms exhibiting the effect of bath application of AMD3100, a selective antagonist of CXCR4, on the absolute values of RMP (b), AP half-width (c), AP rheobase (d), and AP frequency (e) in DRG neurons from saline-treated and BV-treated rats. RMP rest membrane potential, AP action potential; n = 8/group,*P < 0.05, **P < 0.01 BV + vehicle vs. saline + vehicle; #P < 0.05 BV + AMD3100 vs. saline + AMD3100