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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: SDF1–CXCR4 signaling contributes to persistent pain and hypersensitivity via regulating excitability of primary nociceptive neurons: involvement of ERK-dependent Nav1.8 up-regulation

Fig. 6

Effects of intrathecal administration of an ERK inhibitor, U0126, on BV-induced persistent spontaneous nociception and mechanical and thermal hyperalgesia. a Curve graphs showing the effect of U0126 on the persistent spontaneous nociception evaluated by recording the spontaneous paw flinches at each 5 min interval for 1 h immediately after intraplantar BV injection. b Column graphs showing the effect of U0126 on the mean total numbers of paw flinches averaged from the 1 h period intraplantar BV injection. c, d Exhibiting the effects of U0126 on the PWMT and PWTL measured in bilateral hindpaws of BV-treated rats. PWMT paw withdrawal mechanical threshold, PWTL paw withdrawal thermal latency; *P < 0.05, **P < 0.01, ***P < 0.001, n = 6 for each group

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Journal of Neuroinflammation

ISSN: 1742-2094