Fig. 3
From: Ccr2 deletion dissociates cavity size and tau pathology after mild traumatic brain injury
Effects of CCR2 signaling on axonal damage after TBI. Axonal pathology was evaluated at 3 dpi in control heterozygous and Ccr2 RFP/RFP mice by APP staining. a The injury induces APP accumulation in axons of the ipsilateral side to the injury, particularly in the corpus callosum. Ccr2 deletion decreases APP accumulation in axons. Scale bar, 500 μm. b Higher magnification images of the indicated regions (boxes) show that APP immunoreactivity aligns with axonal tracks in the corpus callosum (CC). Scale bar, 100 μm. c Quantification of axonal pathology as percent area of the corpus callosum with APP immunoreactivity above threshold. Statistics: two-way ANOVA and Tukey’s post hoc test. Comparisons between groups are shown with horizontal lines; vertical line in figure legend indicates main effect of genotype. *p < 0.05; **p < 0.01