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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Ccr2 deletion dissociates cavity size and tau pathology after mild traumatic brain injury

Fig. 6

Quantification of pTau Western blots. The levels of pTau (AT8 antibody) were normalized to the levels of total tau (Tau5 antibody). a, b Ccr2 genotype significantly affects pTau levels in both the ipsilateral (a) and contralateral (b) cortex, but pTau levels are elevated after experimental manipulation (surgery or mild injury) only on the ipsilateral side. c, d pTau levels in the hippocampus are increased on both the ipsilateral (c) and contralateral (d) side in injury- and genotype-dependent manner. As in the cortex, sham surgery itself elevates pTau levels in the hippocampus. Statistics: two-way ANOVA and Tukey’s post hoc test. Comparisons between groups are shown with horizontal lines; vertical line in figure legend indicates main effect of genotype. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001

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