From: Low serum ficolin-3 levels are associated with severity and poor outcome in traumatic brain injury
Characteristics | 1-week mortality prediction | 6-month mortality prediction | 6-month functional outcome prediction | ||||||
---|---|---|---|---|---|---|---|---|---|
Non-survivors (n = 20) | Survivors (n = 108) | P value | Non-survivors (n = 40) | Survivors(n = 88) | P value | Unfavorable outcome (n = 64) | Favorable outcome (n = 64) | P value | |
Sex (male/female) | 13/7 | 67/41 | 0.801 | 27/13 | 53/35 | 0.431 | 44/20 | 36/28 | 0.144 |
Age (years) | 45.0 ± 14.5 | 42.1 ± 15.8 | 0.440 | 43.8 ± 15.5 | 41.9 ± 15.7 | 0.522 | 44.6 ± 16.0 | 40.4 ± 15.1 | 0.132 |
Initial postresuscitation GCS score | 3 (1) | 6 (4) | <0.001 | 3 (1) | 6 (3) | <0.001 | 4 (2) | 7 (3) | <0.001 |
Pupils unreactive on admission | 18 (90.0Â %) | 44(40.7Â %) | <0.001 | 32 (80.0Â %) | 30 (34.1Â %) | <0.001 | 43 (80.0Â %) | 19 (34.1Â %) | <0.001 |
CT classification 5 or 6 | 15 (75.0Â %) | 43 (39.8Â %) | 0.004 | 25 (62.5Â %) | 33 (37.5Â %) | 0.008 | 36 (56.3Â %) | 22 (34.4Â %) | 0.013 |
Abnormal cisterns on initial CT scan | 18 (90.0Â %) | 42(38.9Â %) | <0.001 | 29 (72.5Â %) | 31(35.2Â %) | <0.001 | 40 (62.5Â %) | 20(31.3Â %) | <0.001 |
Midline shift >5Â mm on initial CT scan | 17 (85.0Â %) | 48 (44.4Â %) | 0.001 | 30 (75.0Â %) | 35(39.8Â %) | <0.001 | 42 (65.6Â %) | 23(35.9Â %) | 0.001 |
Presence of traumatic SAH on initial CT scan | 16 (80.0Â %) | 54(50.0Â %) | 0.013 | 29 (72.5Â %) | 41(46.6Â %) | 0.006 | 41 (64.1Â %) | 29 (45.3Â %) | 0.033 |
Intracranial surgery in the first 24Â h | 12 (60.0Â %) | 46 (42.6Â %) | 0.151 | 21 (52.2Â %) | 37 (42.1Â %) | 0.271 | 31 (48.4Â %) | 27(42.2Â %) | 0.478 |
Admission time (h) | 2.3 ± 0.9 | 2.5 ± 1.3 | 0.446 | 2.3 ± 0.9 | 2.5 ± 1.4 | 0.384 | 2.3 ± 1.1 | 2.6 ± 1.4 | 0.125 |
Plasma-sampling time (h) | 4.2 ± 1.2 | 3.7 ± 1.6 | 0.183 | 3.7 ± 1.2 | 3.8 ± 1.7 | 0.627 | 3.6 ± 1.5 | 3.9 ± 1.6 | 0.220 |
Systolic arterial pressure (mmHg) | 139.1 ± 22.6 | 128.2 ± 28.0 | 0.105 | 126.7 ± 30.7 | 131.4 ± 25.9 | 0.370 | 126.4 ± 31.2 | 133.5 ± 22.9 | 0.146 |
Diastolic arterial pressure (mmHg) | 81.7 ± 12.6 | 76.7 ± 18.7 | 0.255 | 77.6 ± 16.5 | 77.4 ± 18.6 | 0.942 | 75.5 ± 20.0 | 79.4 ± 15.5 | 0.219 |
Mean arterial pressure (mmHg) | 102.7 ± 15.1 | 95.4 ± 18.8 | 0.100 | 99.0 ± 16.5 | 95.4 ± 19.2 | 0.311 | 95.6 ± 20.4 | 97.4 ± 16.3 | 0.572 |
Plasma C-reactive protein level (mg/L) | 11.1 ± 2.3 | 7.3 ± 3.1 | <0.001 | 10.3 ± 4.1 | 6.8 ± 2.0 | <0.001 | 9.3 ± 3.7 | 6.5 ± 1.9 | <0.001 |
Blood glucose level(mmol/L) | 12.7 ± 4.0 | 9.6 ± 3.1 | 0.002 | 13.6 ± 4.1 | 10.0 ± 3.3 | <0.001 | 12.7 ± 4.0 | 9.6 ± 3.1 | <0.001 |
Serum ficolin-3 levels (μg/mL) | 10.1 ± 4.1 | 16.9 ± 5.6 | <0.001 | 11.4 ± 4.4 | 17.8 ± 5.5 | <0.001 | 12.7 ± 4.5 | 19.0 ± 5.5 | <0.001 |