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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Thalamic inflammation after brain trauma is associated with thalamo-cortical white matter damage

Fig. 1

Increased thalamic microglial activation and white matter damage in TBI. a Statistical parametric maps (reproduced from [3]) rendered onto a standard T1 MRI image showing areas of significantly increased [11C]-PK11195 (PK) binding potentials (BP) in the TBI patients relative to controls. Bilateral increases in PK binding are seen in thalami. t values are shown. Voxels are shown significantly surpassing the voxel-wise threshold (p < 0.001) and the spatial extent threshold (10 voxels). Voxel-wise contrasts were performed on spatially normalised PK BP images, smoothed with a 12-mm full-width at half maximum (FWHM) Gaussian kernel, using SPM5 (see [3] for details). b PK BP in the thalamus and cortical grey matter, defined using anatomical regions of interest, in TBI patients (red) and controls. Group mean ± standard error of the mean (SEM) is shown; ***p < 0.001. c Tract mask (blue) connecting the left thalamus (red) to the left anterior cingulate cortex (ACC) (green), produced using probabilistic tractography in healthy controls (see [12]). Fractional anisotropy (FA) was sampled using bilateral thalamo-cortical tract masks. d FA in thalamo-cortical (Thal-Ctx) body of the corpus callosum (CC) and across the white matter skeleton (Skel) in TBI patients (red) and controls; **p < 0.01

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