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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: CCR5 limits cortical viral loads during West Nile virus infection of the central nervous system

Fig. 2

CCR5 restricts WNV replication in cortical tissues of the CNS. WT and CCR5−/− mice were infected via footpad with 102 PFU of WNV. a Viral burden within the footpad, draining lymph node (popliteal LN), and spleen of WT and CCR5−/− mice were measured at indicated days post-infection. b WNV levels within the cortex, cerebellum, and brainstem were measured at days 6, 8, and 10 post-infection. Tissue homogenates were analyzed for viral burden by infectious plaque assay. Data are shown as the mean PFU per gram of tissue from 6 to 10 mice per time point. Dotted lines denote the limit of detection of the respective assays. Asterisks indicate values that are statistically significant (*P < 0.05)

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