Fig. 3
From: CCR5 limits cortical viral loads during West Nile virus infection of the central nervous system
BBB permeability increases within the cortices of the WNV-infected CCR5−/− CNS. a Following inoculation with 102 PFU of WNV in the footpad, WT and CCR5−/− mice were assessed for BBB sodium fluorescein permeability in different CNS regions on the indicated days post-infection. BBB permeability was determined by the accumulation of sodium fluorescent dye in CNS tissues after intraperitoneal administration. Data are shown as mean fluorescence normalized to the mean value for uninfected animals ± SEM for four mice per time point and are representative of two independent experiments. Asterisks indicate values that are statistically significant (*P < 0.05)