TY - JOUR AU - Paisan-Ruiz, C. AU - Jain, S. AU - Evans, E. W. AU - Gilks, W. P. AU - Simon, J. AU - Brug, M. PY - 2004 DA - 2004// TI - Cloning of the gene containing mutations that cause PARK8-linked Parkinson’s disease JO - Neuron VL - 44 UR - https://doi.org/10.1016/j.neuron.2004.10.023 DO - 10.1016/j.neuron.2004.10.023 ID - Paisan-Ruiz2004 ER - TY - JOUR AU - Zimprich, A. AU - Biskup, S. AU - Leitner, P. AU - Lichtner, P. AU - Farrer, M. AU - Lincoln, S. PY - 2004 DA - 2004// TI - Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology JO - Neuron VL - 44 UR - https://doi.org/10.1016/j.neuron.2004.11.005 DO - 10.1016/j.neuron.2004.11.005 ID - Zimprich2004 ER - TY - JOUR AU - Marin, I. PY - 2006 DA - 2006// TI - The Parkinson disease gene LRRK2: evolutionary and structural insights JO - Mol Biol Evol VL - 23 UR - https://doi.org/10.1093/molbev/msl114 DO - 10.1093/molbev/msl114 ID - Marin2006 ER - TY - JOUR AU - Goldwurm, S. AU - Fonzo, A. AU - Simons, E. J. AU - Rohe, C. F. AU - Zini, M. AU - Canesi, M. PY - 2005 DA - 2005// TI - The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson’s disease and originates from a common ancestor JO - J Med Genet VL - 42 UR - https://doi.org/10.1136/jmg.2005.035568 DO - 10.1136/jmg.2005.035568 ID - Goldwurm2005 ER - TY - JOUR AU - Greggio, E. AU - Jain, S. AU - Kingsbury, A. AU - Bandopadhyay, R. AU - Lewis, P. AU - Kaganovich, A. PY - 2006 DA - 2006// TI - Kinase activity is required for the toxic effects of mutant LRRK2/dardarin JO - Neurobiol Dis VL - 23 UR - https://doi.org/10.1016/j.nbd.2006.04.001 DO - 10.1016/j.nbd.2006.04.001 ID - Greggio2006 ER - TY - JOUR AU - West, A. B. AU - Moore, D. J. AU - Biskup, S. AU - Bugayenko, A. AU - Smith, W. W. AU - Ross, C. A. PY - 2005 DA - 2005// TI - Parkinson’s disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity JO - Proc Natl Acad Sci U S A VL - 102 UR - https://doi.org/10.1073/pnas.0507360102 DO - 10.1073/pnas.0507360102 ID - West2005 ER - TY - JOUR AU - Sheng, Z. AU - Zhang, S. AU - Bustos, D. AU - Kleinheinz, T. AU - Pichon, C. E. AU - Dominguez, S. L. PY - 2012 DA - 2012// TI - Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations JO - Sci Transl Med VL - 4 ID - Sheng2012 ER - TY - JOUR AU - Smith, W. W. AU - Pei, Z. AU - Jiang, H. AU - Dawson, V. L. AU - Dawson, T. M. AU - Ross, C. A. PY - 2006 DA - 2006// TI - Kinase activity of mutant LRRK2 mediates neuronal toxicity JO - Nat Neurosci VL - 9 UR - https://doi.org/10.1038/nn1776 DO - 10.1038/nn1776 ID - Smith2006 ER - TY - JOUR AU - Cirnaru, M. D. AU - Marte, A. AU - Belluzzi, E. AU - Russo, I. AU - Gabrielli, M. AU - Longo, F. PY - 2014 DA - 2014// TI - LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex JO - Front Mol Neurosci VL - 7 UR - https://doi.org/10.3389/fnmol.2014.00049 DO - 10.3389/fnmol.2014.00049 ID - Cirnaru2014 ER - TY - JOUR AU - Matta, S. AU - Kolen, K. AU - Cunha, R. AU - Bogaart, G. AU - Mandemakers, W. AU - Miskiewicz, K. PY - 2012 DA - 2012// TI - LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis JO - Neuron VL - 75 UR - https://doi.org/10.1016/j.neuron.2012.08.022 DO - 10.1016/j.neuron.2012.08.022 ID - Matta2012 ER - TY - JOUR AU - Kett, L. R. AU - Boassa, D. AU - Ho, C. C. AU - Rideout, H. J. AU - Hu, J. AU - Terada, M. PY - 2012 DA - 2012// TI - LRRK2 Parkinson disease mutations enhance its microtubule association JO - Hum Mol Genet VL - 21 UR - https://doi.org/10.1093/hmg/ddr526 DO - 10.1093/hmg/ddr526 ID - Kett2012 ER - TY - JOUR AU - Caesar, M. AU - Zach, S. AU - Carlson, C. B. AU - Brockmann, K. AU - Gasser, T. AU - Gillardon, F. PY - 2013 DA - 2013// TI - Leucine-rich repeat kinase 2 functionally interacts with microtubules and kinase-dependently modulates cell migration JO - Neurobiol Dis VL - 54 UR - https://doi.org/10.1016/j.nbd.2012.12.019 DO - 10.1016/j.nbd.2012.12.019 ID - Caesar2013 ER - TY - STD TI - Civiero L, Cirnaru MD, Beilina A, Rodella U, Russo I, Belluzzi E, et al. LRRK2 interacts with PAK6 to control neurite complexity in mammalian brain. J Neurochem. 2015. ID - ref13 ER - TY - JOUR AU - Papkovskaia, T. D. AU - Chau, K. Y. AU - Inesta-Vaquera, F. AU - Papkovsky, D. B. AU - Healy, D. G. AU - Nishio, K. PY - 2012 DA - 2012// TI - G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization JO - Hum Mol Genet VL - 21 UR - https://doi.org/10.1093/hmg/dds244 DO - 10.1093/hmg/dds244 ID - Papkovskaia2012 ER - TY - JOUR AU - Wang, X. AU - Yan, M. H. AU - Fujioka, H. AU - Liu, J. AU - Wilson-Delfosse, A. AU - Chen, S. G. PY - 2012 DA - 2012// TI - LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1 JO - Hum Mol Genet VL - 21 UR - https://doi.org/10.1093/hmg/dds003 DO - 10.1093/hmg/dds003 ID - Wang2012 ER - TY - JOUR AU - Ho, C. C. AU - Rideout, H. J. AU - Ribe, E. AU - Troy, C. M. AU - Dauer, W. T. PY - 2009 DA - 2009// TI - The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration JO - J Neurosci VL - 29 UR - https://doi.org/10.1523/JNEUROSCI.5175-08.2009 DO - 10.1523/JNEUROSCI.5175-08.2009 ID - Ho2009 ER - TY - JOUR AU - Orenstein, S. J. AU - Kuo, S. H. AU - Tasset, I. AU - Arias, E. AU - Koga, H. AU - Fernandez-Carasa, I. PY - 2013 DA - 2013// TI - Interplay of LRRK2 with chaperone-mediated autophagy JO - Nat Neurosci VL - 16 UR - https://doi.org/10.1038/nn.3350 DO - 10.1038/nn.3350 ID - Orenstein2013 ER - TY - JOUR AU - Gomez-Suaga, P. AU - Luzon-Toro, B. AU - Churamani, D. AU - Zhang, L. AU - Bloor-Young, D. AU - Patel, S. PY - 2012 DA - 2012// TI - Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP JO - Hum Mol Genet VL - 21 UR - https://doi.org/10.1093/hmg/ddr481 DO - 10.1093/hmg/ddr481 ID - Gomez-Suaga2012 ER - TY - JOUR AU - Gardet, A. AU - Benita, Y. AU - Li, C. AU - Sands, B. E. AU - Ballester, I. AU - Stevens, C. PY - 2010 DA - 2010// TI - LRRK2 is involved in the IFN-gamma response and host response to pathogens JO - J Immunol VL - 185 UR - https://doi.org/10.4049/jimmunol.1000548 DO - 10.4049/jimmunol.1000548 ID - Gardet2010 ER - TY - JOUR AU - Schapansky, J. AU - Nardozzi, J. D. AU - Felizia, F. AU - LaVoie, M. J. PY - 2014 DA - 2014// TI - Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy JO - Hum Mol Genet VL - 23 UR - https://doi.org/10.1093/hmg/ddu138 DO - 10.1093/hmg/ddu138 ID - Schapansky2014 ER - TY - JOUR AU - Barrett, J. C. AU - Hansoul, S. AU - Nicolae, D. L. AU - Cho, J. H. AU - Duerr, R. H. AU - Rioux, J. D. PY - 2008 DA - 2008// TI - Genome-wide association defines more than 30 distinct susceptibility loci for Crohn’s disease JO - Nat Genet VL - 40 UR - https://doi.org/10.1038/ng.175 DO - 10.1038/ng.175 ID - Barrett2008 ER - TY - JOUR AU - Zhang, F. R. AU - Huang, W. AU - Chen, S. M. AU - Sun, L. D. AU - Liu, H. AU - Li, Y. PY - 2009 DA - 2009// TI - Genomewide association study of leprosy JO - N Engl J Med VL - 361 UR - https://doi.org/10.1056/NEJMoa0903753 DO - 10.1056/NEJMoa0903753 ID - Zhang2009 ER - TY - JOUR AU - Liu, Z. AU - Lee, J. AU - Krummey, S. AU - Lu, W. AU - Cai, H. AU - Lenardo, M. J. PY - 2011 DA - 2011// TI - The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease JO - Nat Immunol VL - 12 UR - https://doi.org/10.1038/ni.2113 DO - 10.1038/ni.2113 ID - Liu2011 ER - TY - JOUR AU - Kim, B. AU - Yang, M. S. AU - Choi, D. AU - Kim, J. H. AU - Kim, H. S. AU - Seol, W. PY - 2012 DA - 2012// TI - Impaired inflammatory responses in murine Lrrk2-knockdown brain microglia JO - PLoS One VL - 7 UR - https://doi.org/10.1371/journal.pone.0034693 DO - 10.1371/journal.pone.0034693 ID - Kim2012 ER - TY - JOUR AU - Tak, P. P. AU - Firestein, G. S. PY - 2001 DA - 2001// TI - NF-kappaB: a key role in inflammatory diseases JO - J Clin Invest VL - 107 UR - https://doi.org/10.1172/JCI11830 DO - 10.1172/JCI11830 ID - Tak2001 ER - TY - JOUR AU - Ghosh, S. AU - May, M. J. AU - Kopp, E. B. PY - 1998 DA - 1998// TI - NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses JO - Annu Rev Immunol VL - 16 UR - https://doi.org/10.1146/annurev.immunol.16.1.225 DO - 10.1146/annurev.immunol.16.1.225 ID - Ghosh1998 ER - TY - JOUR AU - Zhong, H. AU - May, M. J. AU - Jimi, E. AU - Ghosh, S. PY - 2002 DA - 2002// TI - The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1 JO - Mol Cell VL - 9 UR - https://doi.org/10.1016/S1097-2765(02)00477-X DO - 10.1016/S1097-2765(02)00477-X ID - Zhong2002 ER - TY - JOUR AU - Cheng, C. S. AU - Feldman, K. E. AU - Lee, J. AU - Verma, S. AU - Huang, D. B. AU - Huynh, K. PY - 2011 DA - 2011// TI - The specificity of innate immune responses is enforced by repression of interferon response elements by NF-kappaB p50 JO - Sci Signal VL - 4 UR - https://doi.org/10.1126/scisignal.2001501 DO - 10.1126/scisignal.2001501 ID - Cheng2011 ER - TY - JOUR AU - Ten, R. M. AU - Paya, C. V. AU - Israel, N. AU - Bail, O. AU - Mattei, M. G. AU - Virelizier, J. L. PY - 1992 DA - 1992// TI - The characterization of the promoter of the gene encoding the p50 subunit of NF-kappa B indicates that it participates in its own regulation JO - EMBO J VL - 11 ID - Ten1992 ER - TY - JOUR AU - Napetschnig, J. AU - Wu, H. PY - 2013 DA - 2013// TI - Molecular basis of NF-kappaB signaling JO - Annu Rev Biophys VL - 42 UR - https://doi.org/10.1146/annurev-biophys-083012-130338 DO - 10.1146/annurev-biophys-083012-130338 ID - Napetschnig2013 ER - TY - JOUR AU - Cognet, I. AU - Coignac, A. B. AU - Magistrelli, G. AU - Jeannin, P. AU - Aubry, J. P. AU - Maisnier-Patin, K. PY - 2003 DA - 2003// TI - Expression of recombinant proteins in a lipid A mutant of Escherichia coli BL21 with a strongly reduced capacity to induce dendritic cell activation and maturation JO - J Immunol Methods VL - 272 UR - https://doi.org/10.1016/S0022-1759(02)00506-9 DO - 10.1016/S0022-1759(02)00506-9 ID - Cognet2003 ER - TY - JOUR AU - Codolo, G. AU - Plotegher, N. AU - Pozzobon, T. AU - Brucale, M. AU - Tessari, I. AU - Bubacco, L. PY - 2013 DA - 2013// TI - Triggering of inflammasome by aggregated alpha-synuclein, an inflammatory response in synucleinopathies JO - PLoS One VL - 8 UR - https://doi.org/10.1371/journal.pone.0055375 DO - 10.1371/journal.pone.0055375 ID - Codolo2013 ER - TY - JOUR AU - Marker, D. F. AU - Puccini, J. M. AU - Mockus, T. E. AU - Barbieri, J. AU - Lu, S. M. AU - Gelbard, H. A. PY - 2012 DA - 2012// TI - LRRK2 kinase inhibition prevents pathological microglial phagocytosis in response to HIV-1 Tat protein JO - J Neuroinflammation VL - 9 UR - https://doi.org/10.1186/1742-2094-9-261 DO - 10.1186/1742-2094-9-261 ID - Marker2012 ER - TY - JOUR AU - Moehle, M. S. AU - Webber, P. J. AU - Tse, T. AU - Sukar, N. AU - Standaert, D. G. AU - DeSilva, T. M. PY - 2012 DA - 2012// TI - LRRK2 inhibition attenuates microglial inflammatory responses JO - J Neurosci VL - 32 UR - https://doi.org/10.1523/JNEUROSCI.5601-11.2012 DO - 10.1523/JNEUROSCI.5601-11.2012 ID - Moehle2012 ER - TY - JOUR AU - Dzamko, N. AU - Deak, M. AU - Hentati, F. AU - Reith, A. D. AU - Prescott, A. R. AU - Alessi, D. R. PY - 2010 DA - 2010// TI - Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization JO - Biochem J VL - 430 UR - https://doi.org/10.1042/BJ20100784 DO - 10.1042/BJ20100784 ID - Dzamko2010 ER - TY - JOUR AU - Luerman, G. C. AU - Nguyen, C. AU - Samaroo, H. AU - Loos, P. AU - Xi, H. AU - Hurtado-Lorenzo, A. PY - 2014 DA - 2014// TI - Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1 JO - J Neurochem VL - 128 UR - https://doi.org/10.1111/jnc.12483 DO - 10.1111/jnc.12483 ID - Luerman2014 ER - TY - JOUR AU - Deng, X. AU - Dzamko, N. AU - Prescott, A. AU - Davies, P. AU - Liu, Q. AU - Yang, Q. PY - 2011 DA - 2011// TI - Characterization of a selective inhibitor of the Parkinson’s disease kinase LRRK2 JO - Nat Chem Biol VL - 7 UR - https://doi.org/10.1038/nchembio.538 DO - 10.1038/nchembio.538 ID - Deng2011 ER - TY - JOUR AU - Reith, A. D. AU - Bamborough, P. AU - Jandu, K. AU - Andreotti, D. AU - Mensah, L. AU - Dossang, P. PY - 2012 DA - 2012// TI - GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor JO - Bioorg Med Chem Lett VL - 22 UR - https://doi.org/10.1016/j.bmcl.2012.06.104 DO - 10.1016/j.bmcl.2012.06.104 ID - Reith2012 ER - TY - JOUR AU - Zhang, W. AU - Wang, T. AU - Pei, Z. AU - Miller, D. S. AU - Wu, X. AU - Block, M. L. PY - 2005 DA - 2005// TI - Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson’s disease JO - FASEB J VL - 19 UR - https://doi.org/10.1096/fj.04-2751com DO - 10.1096/fj.04-2751com ID - Zhang2005 ER - TY - JOUR AU - Kim, C. AU - Ho, D. H. AU - Suk, J. E. AU - You, S. AU - Michael, S. AU - Kang, J. PY - 2013 DA - 2013// TI - Neuron-released oligomeric alpha-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia JO - Nat Commun VL - 4 UR - https://doi.org/10.1038/ncomms2534 DO - 10.1038/ncomms2534 ID - Kim2013 ER - TY - JOUR AU - Gestel, J. AU - Leeuw, S. W. PY - 2006 DA - 2006// TI - A statistical-mechanical theory of fibril formation in dilute protein solutions JO - Biophys J VL - 90 UR - https://doi.org/10.1529/biophysj.105.076000 DO - 10.1529/biophysj.105.076000 ID - Gestel2006 ER - TY - JOUR AU - Lu, Y. C. AU - Yeh, W. C. AU - Ohashi, P. S. PY - 2008 DA - 2008// TI - LPS/TLR4 signal transduction pathway JO - Cytokine VL - 42 UR - https://doi.org/10.1016/j.cyto.2008.01.006 DO - 10.1016/j.cyto.2008.01.006 ID - Lu2008 ER - TY - JOUR AU - Daniele, S. G. AU - Beraud, D. AU - Davenport, C. AU - Cheng, K. AU - Yin, H. AU - Maguire-Zeiss, K. A. PY - 2015 DA - 2015// TI - Activation of MyD88-dependent TLR1/2 signaling by misfolded alpha-synuclein, a protein linked to neurodegenerative disorders JO - Sci Signal VL - 8 UR - https://doi.org/10.1126/scisignal.2005965 DO - 10.1126/scisignal.2005965 ID - Daniele2015 ER - TY - JOUR AU - Wan, F. AU - Lenardo, M. J. PY - 2009 DA - 2009// TI - Specification of DNA binding activity of NF-kappaB proteins JO - Cold Spring Harb Perspect Biol VL - 1 UR - https://doi.org/10.1101/cshperspect.a000067 DO - 10.1101/cshperspect.a000067 ID - Wan2009 ER - TY - JOUR AU - Guan, H. AU - Hou, S. AU - Ricciardi, R. P. PY - 2005 DA - 2005// TI - DNA binding of repressor nuclear factor-kappaB p50/p50 depends on phosphorylation of Ser337 by the protein kinase A catalytic subunit JO - J Biol Chem VL - 280 UR - https://doi.org/10.1074/jbc.M412180200 DO - 10.1074/jbc.M412180200 ID - Guan2005 ER - TY - JOUR AU - Hou, S. AU - Guan, H. AU - Ricciardi, R. P. PY - 2003 DA - 2003// TI - Phosphorylation of serine 337 of NF-kappaB p50 is critical for DNA binding JO - J Biol Chem VL - 278 UR - https://doi.org/10.1074/jbc.M307971200 DO - 10.1074/jbc.M307971200 ID - Hou2003 ER - TY - JOUR AU - Parisiadou, L. AU - Yu, J. AU - Sgobio, C. AU - Xie, C. AU - Liu, G. AU - Sun, L. PY - 2014 DA - 2014// TI - LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity JO - Nat Neurosci VL - 17 UR - https://doi.org/10.1038/nn.3636 DO - 10.1038/nn.3636 ID - Parisiadou2014 ER - TY - JOUR AU - Baeuerle, P. A. AU - Baltimore, D. PY - 1996 DA - 1996// TI - NF-kappa B: ten years after JO - Cell VL - 87 UR - https://doi.org/10.1016/S0092-8674(00)81318-5 DO - 10.1016/S0092-8674(00)81318-5 ID - Baeuerle1996 ER - TY - JOUR AU - Glass, D. B. AU - Lundquist, L. J. AU - Katz, B. M. AU - Walsh, D. A. PY - 1989 DA - 1989// TI - Protein kinase inhibitor-(6–22)-amide peptide analogs with standard and nonstandard amino acid substitutions for phenylalanine 10. Inhibition of cAMP-dependent protein kinase JO - J Biol Chem VL - 264 ID - Glass1989 ER - TY - JOUR AU - Hirsch, E. C. AU - Hunot, S. PY - 2009 DA - 2009// TI - Neuroinflammation in Parkinson’s disease: a target for neuroprotection? JO - Lancet Neurol VL - 8 UR - https://doi.org/10.1016/S1474-4422(09)70062-6 DO - 10.1016/S1474-4422(09)70062-6 ID - Hirsch2009 ER - TY - JOUR AU - Russo, I. AU - Bubacco, L. AU - Greggio, E. PY - 2014 DA - 2014// TI - LRRK2 and neuroinflammation: partners in crime in Parkinson’s disease? JO - J Neuroinflammation VL - 11 UR - https://doi.org/10.1186/1742-2094-11-52 DO - 10.1186/1742-2094-11-52 ID - Russo2014 ER - TY - JOUR AU - Schapansky, J. AU - Nardozzi, J. D. AU - LaVoie, M. J. PY - 2015 DA - 2015// TI - The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson’s disease JO - Neuroscience VL - 302 UR - https://doi.org/10.1016/j.neuroscience.2014.09.049 DO - 10.1016/j.neuroscience.2014.09.049 ID - Schapansky2015 ER - TY - JOUR AU - Puccini, J. M. AU - Marker, D. F. AU - Fitzgerald, T. AU - Barbieri, J. AU - Kim, C. S. AU - Miller-Rhodes, P. PY - 2015 DA - 2015// TI - Leucine-rich repeat kinase 2 modulates neuroinflammation and neurotoxicity in models of human immunodeficiency virus 1-associated neurocognitive disorders JO - J Neurosci VL - 35 UR - https://doi.org/10.1523/JNEUROSCI.0650-14.2015 DO - 10.1523/JNEUROSCI.0650-14.2015 ID - Puccini2015 ER - TY - JOUR AU - Tansey, M. G. AU - McCoy, M. K. AU - Frank-Cannon, T. C. PY - 2007 DA - 2007// TI - Neuroinflammatory mechanisms in Parkinson’s disease: potential environmental triggers, pathways, and targets for early therapeutic intervention JO - Exp Neurol VL - 208 UR - https://doi.org/10.1016/j.expneurol.2007.07.004 DO - 10.1016/j.expneurol.2007.07.004 ID - Tansey2007 ER - TY - JOUR AU - Kim, W. G. AU - Mohney, R. P. AU - Wilson, B. AU - Jeohn, G. H. AU - Liu, B. AU - Hong, J. S. PY - 2000 DA - 2000// TI - Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia JO - J Neurosci VL - 20 ID - Kim2000 ER - TY - JOUR AU - Fellner, L. AU - Irschick, R. AU - Schanda, K. AU - Reindl, M. AU - Klimaschewski, L. AU - Poewe, W. PY - 2013 DA - 2013// TI - Toll-like receptor 4 is required for alpha-synuclein dependent activation of microglia and astroglia JO - Glia VL - 61 UR - https://doi.org/10.1002/glia.22437 DO - 10.1002/glia.22437 ID - Fellner2013 ER - TY - JOUR AU - Watson, M. B. AU - Richter, F. AU - Lee, S. K. AU - Gabby, L. AU - Wu, J. AU - Masliah, E. PY - 2012 DA - 2012// TI - Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein JO - Exp Neurol VL - 237 UR - https://doi.org/10.1016/j.expneurol.2012.06.025 DO - 10.1016/j.expneurol.2012.06.025 ID - Watson2012 ER - TY - JOUR AU - Daher, J. P. AU - Volpicelli-Daley, L. A. AU - Blackburn, J. P. AU - Moehle, M. S. AU - West, A. B. PY - 2014 DA - 2014// TI - Abrogation of alpha-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats JO - Proc Natl Acad Sci U S A VL - 111 UR - https://doi.org/10.1073/pnas.1403215111 DO - 10.1073/pnas.1403215111 ID - Daher2014 ER - TY - JOUR AU - Gillardon, F. AU - Schmid, R. AU - Draheim, H. PY - 2012 DA - 2012// TI - Parkinson’s disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity JO - Neuroscience VL - 208 UR - https://doi.org/10.1016/j.neuroscience.2012.02.001 DO - 10.1016/j.neuroscience.2012.02.001 ID - Gillardon2012 ER - TY - JOUR AU - Hatcher, J. M. AU - Zhang, J. AU - Choi, H. G. AU - Ito, G. AU - Alessi, D. R. AU - Gray, N. S. PY - 2015 DA - 2015// TI - Discovery of a pyrrolopyrimidine (JH-II-127), a highly potent, selective, and brain penetrant LRRK2 inhibitor JO - ACS Med Chem Lett VL - 6 UR - https://doi.org/10.1021/acsmedchemlett.5b00064 DO - 10.1021/acsmedchemlett.5b00064 ID - Hatcher2015 ER - TY - JOUR AU - Koshibu, K. AU - Asperen, J. AU - Gerets, H. AU - Garcia-Ladona, J. AU - Lorthioir, O. AU - Courade, J. P. PY - 2015 DA - 2015// TI - Alternative to LRRK2-IN-1 for pharmacological studies of Parkinson’s disease JO - Pharmacology VL - 96 UR - https://doi.org/10.1159/000439136 DO - 10.1159/000439136 ID - Koshibu2015 ER - TY - JOUR AU - Henderson, J. L. AU - Kormos, B. L. AU - Hayward, M. M. AU - Coffman, K. J. AU - Jasti, J. AU - Kurumbail, R. G. PY - 2015 DA - 2015// TI - Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor JO - J Med Chem VL - 58 UR - https://doi.org/10.1021/jm5014055 DO - 10.1021/jm5014055 ID - Henderson2015 ER - TY - JOUR AU - Munoz, L. AU - Kavanagh, M. E. AU - Phoa, A. F. AU - Heng, B. AU - Dzamko, N. AU - Chen, E. J. PY - 2015 DA - 2015// TI - Optimisation of LRRK2 inhibitors and assessment of functional efficacy in cell-based models of neuroinflammation JO - Eur J Med Chem VL - 95 UR - https://doi.org/10.1016/j.ejmech.2015.03.003 DO - 10.1016/j.ejmech.2015.03.003 ID - Munoz2015 ER - TY - JOUR AU - Li, T. AU - He, X. AU - Thomas, J. M. AU - Yang, D. AU - Zhong, S. AU - Xue, F. PY - 2015 DA - 2015// TI - A novel GTP-binding inhibitor, FX2149, attenuates LRRK2 toxicity in Parkinson’s disease models JO - PLoS One VL - 10 UR - https://doi.org/10.1371/journal.pone.0122461 DO - 10.1371/journal.pone.0122461 ID - Li2015 ER - TY - JOUR AU - Daher, J. P. AU - Abdelmotilib, H. A. AU - Hu, X. AU - Volpicelli-Daley, L. A. AU - Moehle, M. S. AU - Fraser, K. B. PY - 2015 DA - 2015// TI - Leucine-rich repeat kinase 2 (LRRK2) pharmacological inhibition abates alpha-synuclein gene-induced neurodegeneration JO - J Biol Chem VL - 290 UR - https://doi.org/10.1074/jbc.M115.660001 DO - 10.1074/jbc.M115.660001 ID - Daher2015 ER - TY - JOUR AU - Fuji, R. N. AU - Flagella, M. AU - Baca, M. AU - MA, S. B. AU - Brodbeck, J. AU - Chan, B. K. PY - 2015 DA - 2015// TI - Effect of selective LRRK2 kinase inhibition on nonhuman primate lung JO - Sci Transl Med VL - 7 ID - Fuji2015 ER - TY - JOUR AU - Miklavc, P. AU - Ehinger, K. AU - Thompson, K. E. AU - Hobi, N. AU - Shimshek, D. R. AU - Frick, M. PY - 2014 DA - 2014// TI - Surfactant secretion in LRRK2 knock-out rats: changes in lamellar body morphology and rate of exocytosis JO - PLoS One VL - 9 UR - https://doi.org/10.1371/journal.pone.0084926 DO - 10.1371/journal.pone.0084926 ID - Miklavc2014 ER - TY - JOUR AU - Hakimi, M. AU - Selvanantham, T. AU - Swinton, E. AU - Padmore, R. F. AU - Tong, Y. AU - Kabbach, G. PY - 2011 DA - 2011// TI - Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures JO - J Neural Transm (Vienna) VL - 118 UR - https://doi.org/10.1007/s00702-011-0653-2 DO - 10.1007/s00702-011-0653-2 ID - Hakimi2011 ER -