Fig. 1
From: Pro-inflammatory pattern of IgG1 Fc glycosylation in multiple sclerosis cerebrospinal fluid
Scheme of the IgG Fc glycan structure and quantitative values for sugar residues in control CSF IgG1. The main variable sugar residues and their presumed pro- and anti-inflammatory properties are indicated: terminal sialic acid (N-acetylneuraminic acid) and galactose residues act mainly anti-inflammatory, whereas bisecting N-acetylglucosamines (GlcNAc) act mainly pro-inflammatory. Core fucosylation decreases ADCC, but in addition was reported to increase complement activation (Gasdaska et al. 2012). Median percentages of the presence of the variable sugar residues on IgG1 in our human control CSF samples are indicated. Symbols and colors are drawn according to the Consortium for Functional Glycomics [55]. Asn297 asparagine 297, in the Fc part of IgG