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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Pro-inflammatory pattern of IgG1 Fc glycosylation in multiple sclerosis cerebrospinal fluid

Fig. 4

IgG1 Fc glycosylation is significantly altered in the CSF from MS patients vs. controls (elevated; bisecting GlcNAc; reduced; galactosylation and afucosylation). a-d Individual glycosylation features. CSF IgG1 glycosylation (normalized to serum IgG1 glycosylation) is displayed. Significance was determined using Mann-Whitney U test, followed by Bonferroni correction for multiple testing (p adj). Factors above diagrams indicate fold-changes. e Principal component analysis, incorporating the CSF/serum ratios of all four variable sugar residues, separated the MS from the control group better than each individual sugar residue. Symbols represent individual donors (MS; orange triangles; controls; blue circles). Dotted gray vectors represent loadings. f Principal component analysis variances. Individual (bars, left axis) and cumulative (points, right axis in green) variances for the principal components are shown. In the score plot (e, showing the first two components), 85 % of the total cumulative variance is incorporated

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