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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Pro-inflammatory pattern of IgG1 Fc glycosylation in multiple sclerosis cerebrospinal fluid

Fig. 5

Relationship between glycosylation and time since last relapse. Left part (scatterplots); afucosylation (a) and bisecting GlcNAc (b) in the CSF were plotted against the time since the last relapse. Samples from patients who did not have a relapse within 1 year of sampling were plotted at a cutoff of 1 year. Hypothesis-free regression was computed using the LOWESS method (red curve), demonstrating a peak of alterations 2–3 months after the last relapse. The period of the peak, defined by the crossings of the red LOWESS line with the median of all MS samples (horizontal line) was designated as peak period (gray area). Right part (boxplots): Samples from within this peak period were compared with samples outside of this period, and in addition also with control samples (one-sided U test according to the directed hypothesis, followed by Bonferroni correction for the four IgG1 glycofeatures tested)

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