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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Loss of intraepidermal nerve fiber density during SIV peripheral neuropathy is mediated by monocyte activation and elevated monocyte chemotactic proteins

Fig. 2

Correlates of plasma markers of monocyte activation and monocyte chemoattractants. sCD14 (ac), sCD163 (df), RANTES (gi), MCP-1 (jl), and sCD137 (mo) were measured in plasma at multiple time points throughout infection. a, d, g, j, and m Pre-infection and necropsy plasma concentrations were compared using a Wilcoxon matched-pairs signed-rank test. Necropsy plasma concentrations were grouped according to the lumbar DRG pathology and compared using a Kruskal-Wallis test. The number of BrdU+ monocytes in blood (b, e, h, k, n) and the percent of CD14+ CD16+ monocytes of the total monocyte population (c, f, i, l, o) was determined by flow cytometry and correlated to the plasma soluble protein concentrations at matched time points. A Spearman correlation test was used for all correlations. p value of <0.05 was considered significant

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