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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Progesterone treatment reduces neuroinflammation, oxidative stress and brain damage and improves long-term outcomes in a rat model of repeated mild traumatic brain injury

Fig. 3

PROG treatment attenuates brain atrophy after rFPI. As shown in the representative T2-weighted MRI images (ad), rFPI + VEH rats had significantly less volume of the ipsilateral cortex (e) and ipsilateral hippocampus (f) than all other groups, whereas the rFPI + PROG group did not significantly differ from SHAM groups. PROG-treated rats also had increased volume of the ipsilateral corpus callosum (g), contralateral corpus callosum (g) and contralateral cortex (e) and smaller lateral ventricles (h). Rats given rFPI had reduced volume of contralateral hippocampus (f), ipsilateral corpus callosum (g), contralateral corpus callosum (g) and larger lateral ventricles (h). Triple asterisks significantly different from all other groups, number sign significant treatment effect, single asterisk significant injury effect, p < 0.05

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