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Table 1 Acute post-injury outcomes

From: Progesterone treatment reduces neuroinflammation, oxidative stress and brain damage and improves long-term outcomes in a rat model of repeated mild traumatic brain injury

  Injury 1 Injury 2 Injury 3
  Hind limb Self-righting Hind limb Self-righting Hind limb Self-righting
SHAM + VEH 0 ± 0 98.9 ± 5.2 0 ± 0 98.1 ± 6.5 0 ± 0 93.3 ± 5.0
SHAM + PROG 0 ± 0 101.8 ± 5.8 0 ± 0 99.2 ± 6.4 0 ± 0 96.1 ± 7.4
rFPI + VEH 0.83 ± .56* 149.2 ± 13.4* 2.08 ± .96* 159.9 ± 13.7* 1.25 ± .90* 160.2 ± 9.6*
rFPI + PROG 1.15 ± .61* 158.7 ± 13.0* 1.54 ± .67* 150.2 ± 10.5* 1.54 ± .87* 154.5 ± 8.0*
  1. Regardless of the assigned treatment, rFPI resulted in worse acute injury severity outcomes as indicated by increased hind limb withdrawal and self-righting reflex times compared to the SHAM groups. There was no apnea observed after any of the injuries
  2. *rFPI significantly greater than sham-injured groups, p < 0.001