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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Multipotent adult progenitor cells for hypoxic-ischemic injury in the preterm brain

Fig. 3

MAPC reduced cerebral inflammation in the subcortical white matter (SCWM), but not in the hippocampus. ab Immunohistochemical IBA-1 staining in the SCWM at ×20 (a) and ×200 (b) magnification and hippocampus of the four experimental groups (sham-SAL n = 8, sham-MAPC n = 5, HI-SAL n = 8, HI-MAPC n = 5). Global HI induced a profound increase of IBA-1 immunoreactivity and amoeboid morphology in both regions, which was significantly reduced by MAPC in the SCWM, but not in the hippocampus. cd Graphical presentation of area fraction of IBA-1 immunoreactivity in SCWM and hippocampus. Geometric means ± 95 % CI and levels of significance are depicted, which were calculated by the random intercept model with all repeated measures (i.e., brain sections) per animal. ef Immunohistochemical IBA-1 staining in the hippocampus at ×20 (e) and ×200 (f) magnification of the four experimental groups. IBA-1 IR was markedly increased and accompanied by amoeboid morphology following global HI, which remained unaffected after MAPC treatment (sham-SAL n = 8, sham-MAPC n = 5, HI-SAL n = 8, HI-MAPC n = 5). *P ≤ 0.05, §P ≤ 0.01, #P ≤ 0.001. IBA-1 ionized calcium-binding adaptor molecule 1, HI hypoxia-ischemia, SAL saline, MAPC multipotent adult progenitor cells, IR immunoreactivity. ab Scale bars: ae represent 1 mm, bf 100 μm

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