Fig. 6

MAPC induced functional neuroprotection after global HI. Global HI caused a significant seizure burden indicated by an increased total number (a) and duration of seizures (b) compared to controls. Administration of MAPC significantly reduced electrographic seizure number and duration. Medians ± interquartile ranges (IQR) and levels of significance of the treatment effect (HI-SAL vs. HI-MAPC) are depicted, which were calculated by Mann-Whitney test (HI-SAL n = 8, HI-MAPC n = 8). No electrographic seizure activity was detected under sham conditions. For clarity purposes these sham groups (sham-SAL n = 8 and sham-MAPC n = 6) are not shown. *P ≤ 0.05, §P ≤ 0.01, #P ≤ 0.001. HI hypoxia-ischemia, SAL saline, MAPC multipotent adult progenitor cells