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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Identification of a novel mechanism of action of fingolimod (FTY720) on human effector T cell function through TCF-1 upregulation

Fig. 5

RRMS T cells show decreased TCF7 expression. a Expression of TCF7 in ex vivo T cells from RRMS patients (T-RRMS, n = 26) and healthy individuals (T-CTL, n = 21) measured using qPCR. b Expression of TCF7 in activated T-RRMS cells (n = 18) and T-CTL cells (n = 19) measured using qPCR. c TCF7 expression measured by qPCR in in vitro activated T cells from RRMS patients (n = 10) in the presence or absence of FTY720. d Correlation between TCF7 expression and EDSS score. *p < 0.05, **p < 0.01, ***p < 0.001, unpaired non-parametric t tests and Spearman correlation

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