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Fig. 11 | Journal of Neuroinflammation

Fig. 11

From: Modulation of post-stroke degenerative and regenerative processes and subacute protection by site-targeted inhibition of the alternative pathway of complement

Fig. 11

CR2-fH localizes to the brain after MCAO and specifically targets the ipsilateral lesion site. Fluorescently labeled CR2-fH was administered as described for therapeutic protocol, and localization of CR2-fH was visualized by in vivo fluorescence tomography. a Representative images of head scans of a single mouse taken at indicated times. b Quantification of fluorescent signal. Mean +/− SEM, n = 5 (24–72 h), n = 4 (72 h), n = 3 (7 days). c, Ex vivo image of brain removed 7 days after MCAO and injection of labeled CR2-fH (lower) or PBS (upper)

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