Fig. 3

Effect of complement inhibition on behavioral deficit and locomotor function after MCAO. a Neurological deficit scores (0–4) within the first week after MCAO. Mean +/− SEM, n = 8–13. One-way ANOVA, **p < 0.05 (wild-type compared to all other groups), *p < 0.05 (wild-type compared to CR2-fH only). b Anxiety assessment across the different groups measured as percent time spent at the center of an open field. Mean +/− SEM. (One-way ANOVA, n.s. p > 0.05). c, d Locomotor activity measured as total distance moved (c) or number of movements (d), using an open field activity monitor. Determinations were made 2, 3, and 7 days after MCAO. Mean +/− SEM, n = 8–13. One-way ANOVA, *p < 0.05(CR2-fH-treated compared to wild-type)