Fig. 9

CR2-fH improves cognitive performance 7 days post-MCAO. a CR2-fH improves performance on passive avoidance task 7 days after MCAO. Shown is latency to enter a dark box associated with a shock. Mice were given a trial to associate a shock with the dark side of an apparatus, and latency to enter dark side was evaluated on days 3 and 7 post-MCAO. Mean +/− SEM, n = 7–10, *p < 0.05. b–d, CR2-fH reduces spatial memory deficits in Barnes maze task in the subacute phase after MCAO. Mice were trained on the maze for 5 days before surgery and then tested on days 3 and 7 after MCAO for latency to escape (b), path length (c), and number of error pokes (d). Mean +/− SEM, n = 9–10, *p < 0.05, **p < 0.01