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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Acid-sensing ion channel 1a contributes to the effect of extracellular acidosis on NLRP1 inflammasome activation in cortical neurons

Fig. 2

Extracellular acidosis reduces [K+] i by BK channel in cortical neurons. a Statistical results showing low pH extracellular medium reduced [K] i . b Representative traces showing recorded potassium currents were markedly inhibited by specific BK channel inhibitor IbTX. c Representative traces and statistical results showing low pH extracellular medium increased BK currents. d Representative traces and statistical results showing low pH extracellular medium failed to increase BK currents in the presence of IbTX. e Statistical results showing IbTX attenuated acidosis-induced decrease in [K] i . Data are expressed as means ± SEM. n = 6, # p < 0.05 vs control and *p < 0.05 vs pH 6.5

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