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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Acid-sensing ion channel 1a contributes to the effect of extracellular acidosis on NLRP1 inflammasome activation in cortical neurons

Fig. 4

ASICs mediate the increase of BK currents and the decrease of [K+] i induced by extracellular acidosis. a Representative traces and statistical results showing amiloride did not influence BK currents at neutral pH. b Representative traces and statistical results showing amiloride inhibited acidosis-induced increase of BK currents. c Representative traces and statistical results showing PcTX1 did not influence BK currents at neutral pH. d Representative traces and statistical results showing PcTX1 inhibited acidosis-induced increase of BK currents. e, f Representative traces and statistical results showing acidosis failed to increase BK currents after pretreatment with PcTX1. g PcTX1 attenuated acidosis-induced decrease in [K+] i . Data are expressed as means ± SEM. n = 6, # p < 0.05 vs control and *p < 0.05 vs pH 6.5

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Journal of Neuroinflammation

ISSN: 1742-2094