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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Acid-sensing ion channel 1a contributes to the effect of extracellular acidosis on NLRP1 inflammasome activation in cortical neurons

Fig. 7

Neutralization of NLRP1 protects against neuronal injury induced by extracellular acidosis. a, b Statistical results showing NLRP1 neutralization attenuated acidosis-induced decrease in cell viability and increase in LDH release. c, d Representative immunoreactive bands and statistical results showing NLRP1 neutralization attenuated acidosis-induced decrease in ratio of Bcl-2/Bax and increase in expression of activated caspase-3. Data are expressed as means ± SEM. n = 6, ## p < 0.01 vs control, *p < 0.05 and **p < 0.01 vs pH 6.5

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Journal of Neuroinflammation

ISSN: 1742-2094