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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Non-alcoholic fatty liver disease induces signs of Alzheimer’s disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model

Fig. 2

HFD induced acute liver pathology and inflammation in WT and APP-Tg and mice. a Representative images of livers from WT or APP-Tg mice fed with HFD or SD, with corresponding liver and body weights of their respective age-matched SD-fed controls. Scale bar indicates 5 mm (b). ** and *** indicate p < 0.01 and p < 0.001, respectively (two-way ANOVA with Bonferroni post-test). c Representative CD45+ staining of liver sections from WT or APP-Tg mice fed with SD or HFD for 2 months. d Representative oil O-red staining on frozen tissue sections of livers from WT or APP-Tg mice fed with SD or HFD for 2 months. e Relative positive pixel count of oil O-red staining quantified using Zen software (Carl Zeiss). * and *** indicate p < 0.05 and p < 0.001, respectively (two-way ANOVA with Bonferroni post-test). f Quantitative analysis of total leukocyte numbers (CD45+) isolated from the livers of 2-month SD or HFD-fed WT and APP-Tg mice by flow cytometry. ** indicates p < 0.01 (two-way ANOVA with Bonferroni post-test, n = 3/group). g TNF-α, IL-6, and IL-17 mRNA expression in livers of WT and APP-Tg mice fed with SD or HFD for 2 months. ** indicates p < 0.01 (two-way ANOVA with Bonferroni post-test, n = 3/group, representative experiment of four independent experiments)

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