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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary microglia

Fig. 5

Signal transduction pathways involved in the poly(I:C)-mediated induction of COX-2 and mPGES-1 in rat primary microglia. It is shown here that poly(I:C) induced COX-2 and mPGES-1 proteins, as well as PGE2 production, and by using pharmacological inhibitors against various signaling pathways including p38 MAPK, JNK, MEK1/2, and IKK2, these poly(I:C) effects on COX-2 and mPGES-1 were reversed. Furthermore, inhibition of mTOR and PI3K or dual inhibition of PI3K/mTOR enhanced the immunoreactivity of COX-2

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