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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: CXCL5 signaling is a shared pathway of neuroinflammation and blood–brain barrier injury contributing to white matter injury in the immature brain

Fig. 3

CXCL5 expression in the normal developing rat brain. a CXCL5 immunohistochemical analysis demonstrated that P7 (n = 4) and, particularly, P2 pups (n = 5) had significantly higher CXCL5 expression in the cerebral cortex than that of P30 rats (n = 4). Values are means ± SEMs. The P2 pups had significantly higher CXCL5 expression in the cerebral cortex than that of the P7 pups and P30 rats. CXCL5 expression was low in the white matter, and no significant difference was observed between the three groups. b Immunofluorescence staining in the P2 pups revealed that the most CXCL5-positive cells in the cortex were neurons (NeuN) rather than microglia (ED1), and CXCL5 expression was absent in all white matter cells. c Scale bar = 50 μm

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Journal of Neuroinflammation

ISSN: 1742-2094