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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Exosomes derived from atorvastatin-modified bone marrow dendritic cells ameliorate experimental autoimmune myasthenia gravis by up-regulated levels of IDO/Treg and partly dependent on FasL/Fas pathway

Fig. 4

Statin-Dex treatment increases the number of Foxp3+ cells in thymus of EAMG rats. The number of Foxp3+ cells in thymus of EAMG rats was analyzed by immunohistochemistry. Statin-Dex, control-Dex, and PBS were transferred into EAMG rats via tail vein injection. Rats were sacrificed on day 43 p.i. a Representative micrographs show more Foxp3+ cells in the thymus in rats treated with statin-Dex compared to those in control-Dex and control rats, respectively. The arrow referred to typical Foxp3+ cells and the nucleus was filled with brown. Original magnification, ×200 and ×400. b The number of Foxp3+ cells per mm2 thymus sections is expressed as mean ± SD (n = 5 rats per group) (***p < 0.001)

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