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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Neuroprotective effects of bee venom phospholipase A2 in the 3xTg AD mouse model of Alzheimer’s disease

Fig. 4

bvPLA2 reduces neuroinflammatory responses and the infiltration of CD4+ T cells into the hippocampi of 3xTg-AD mice. Treatment with bvPLA2 induced microglial deactivation in the hippocampal CA1 (a, e) and CA3 regions (b, f). Treatment with bvPLA2 induced reductions in CD4+ T cell infiltration in the hippocampal CA1 (c, g) and CA3 regions (d, h). The representative immunostained cells were indicated as arrows (ad). The error bars indicate the SEMs. **P < 0.01, ***P < 0.001 compared to the WT groups; #P < 0.05, ##P < 0.01 compared to the 3xTg group (one-way ANOVA with Tukey’s post hoc analyses)

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