Skip to main content
Fig. 10 | Journal of Neuroinflammation

Fig. 10

From: Apocynin prevents mitochondrial burdens, microglial activation, and pro-apoptosis induced by a toxic dose of methamphetamine in the striatum of mice via inhibition of p47phox activation by ERK

Fig. 10

A schematic depiction of the role of PHOX in MA-induced ERK-dependent dopaminergic neurotoxicity. Treatment with a toxic dose of MA resulted in significant phosphorylations in ERK1/2 (> p38 and JNK), and p47phox followed by membrane translocation of p47phox in the striatum of mice. The activation of p47phox promotes mitochondrial stress followed by microglial activation into M1 phenotype, and pro-apoptotic process, and leading to dopaminergic impairments. These signalings were promoted by ERK1/2. ERK inhibitor U0126 did not exhibit any additional positive effect in response to the protection offered by apocynin or p47phox genetic inhibition, suggesting that ERK regulates p47phox activation, and thus ERK is the crucial target for apocynin-mediated inhibition of PHOX activation

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094