Fig. 2

Effects of U0126 and apocynin or p47phox knockout against MA-induced activations in ERK and p47phox. Phosphorylation of ERK (a) and phosphorylation (b) and membrane translocation (c) of p47phox after MA (35 mg/kg, i.p.). WT wild-type mice, p47 KO p47phox knockout mice, Sal saline, U U0126 (2 μg, i.c.v.), Apo apocynin (50 mg/kg, i.p.), V or Veh vehicle [10 % (v/v) DMSO] for U0126 or apocynin. Each value is the mean ± SEM of six animals. ^** P < 0.01, ^& P < 0.001 vs. vehicle/WT with saline. ^# P < 0.05 or ^## P < 0.01 vs. vehicle/WT with MA (three-way ANOVA was followed by Fisher’s LSD pairwise comparisons)