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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Urban traffic-derived nanoparticulate matter reduces neurite outgrowth via TNFα in vitro

Fig. 5

TNFα siRNA rescued the inhibition of neurite outgrowth in nPM-CM. a CM from glia cultures transfected with siRNA to TNFα showed a rescue of total neurite outgrowth vs control cultures transfected with scrambled siRNA and treated with nPM (**p < 0.01, ***p < 0.001; ANOVA with Tukey’s post-test). b Neurite number, not altered by treatment. c Neurite-associated βIII-tubulin changed in parallel with total neurite length. d Neuronal perikaryal area, not altered by treatment. e Mean axon length shortening by nPM treatment was rescued with TNFα siRNA. f Neurons treated with nPM or scrambled siRNA + nPM mixed glial CM had shorter neurites (**p < 0.01; two-way ANOVA with Tukey’s post-test; avg. three experiments)

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