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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Complement component C3a plays a critical role in endothelial activation and leukocyte recruitment into the brain

Fig. 5

The C3a receptor is essential for LPS-induced leukocyte recruitment into the brain vasculature. a WT C57BL/6J mice were i.c.v.-treated with LPS, and C3a levels in brain and plasma were then measured at 0, 4, 12, and 24 h after LPS injection by ELISA. WT BALB/c mice, C3aR−/− mice, WT C57BL/6J mice, and C5aR−/− mice were i.c.v.-treated with LPS, and 4 h later, intravital microscopy was performed. Leukocyte rolling flux and adhesion (bc) are shown as the means ± SEM. **P < 0.01; n ≥ 4 for all groups

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