Fig. 2

Impact of IPS signaling on chemokine, cytokine, and ISG expression upon virus infection. WT and IPS-1 ^−/− mice were infected intraperitoneally with 10⁴ FFU of LGTV, and the brains were harvested on 0, 4, and 7 dpi. Expression levels of IFN-β, IFN-α4, IFN-λ, Mx1, viperin, IL6, CCL5, and CXCL10 were determined by real-time RT-PCR (a–h). Data represent the mean and standard error of the mean (SEM) of five to six mice per time point from at least two independent experiments. Asterisks indicates statistical significance calculated by Mann-Whitney test, **p < 0.01