Skip to main content
Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Sodium thiosulfate attenuates glial-mediated neuroinflammation in degenerative neurological diseases

Fig. 5

a Contribution of TNFα and IL-6 released from LPS/IFNγ-stimulated microglia on SH-5Y5Y cell viability. Direct treatment of RA-differentiated SH-SY5Y cells with TNFα (800 pg/ml) and/or IL-6 (600 pg/ml) was not changed SH-SY5Y cell viability (TNFa, IL-6, and TNFa + IL-6 in x-axis). Effects of removing TNFα and/or IL-6 using their specific antibody (ELISA methods) from neurotoxic secretions from microglia stimulated with LPS/IFNγ (TNFa Ab, IL-6 Ab, and TNFa Ab + IL-6 Ab in x-axis). CON and ST mean unstimulation and stimulation, respectively. See “Methods” section for details. One-way ANOVA was carried out to test significance. *P < 0.01 vs CON group, **P < 0.01 vs ST group, and ***P < 0.01 vs TNFa Ab and IL-6 Ab groups. b Contribution of IL-6 released from IFNγ-stimulated astrocytes on SH-5Y5Y cell viability. For details, see “Methods” section. Direct treatment of RA-differentiated SH-SY5Y cells with IL-6 (120 ng/ml) was not changed SH-SY5Y cell viability (IL-6 in x-axis). Effects of removing IL-6 using their specific antibody (ELISA methods) from neurotoxic secretions from astrocytes stimulated with IFNγ (IL-6 Ab in x-axis). CON and ST mean unstimulation and stimulation, respectively. See “Methods” section for details. One-way ANOVA was carried out to test significance. *P < 0.01 vs CON group and **P < 0.01 vs ST group

Back to article page