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Table 3 IC50 (μM) based on MTT (A-1 and B-1) and LDHR data (A-2 and B-2) of NaSH and STS at different pre-incubation times in microglia and astrocytes

From: Sodium thiosulfate attenuates glial-mediated neuroinflammation in degenerative neurological diseases

Human microglia and astrocytes

(B) MTT data

 

Miroglia

Astrocytes

Pre-incubation time

NaSH

STS

NaSH

STS

8 h

7.62 ± 0.46

68.43 ± 3.25 *

9.01 ± 0.71

77.53 ± 3.48 *

(B) LDHR data

 

Miroglia

Astrocytes

Pre-incubation time

NaSH

STS

NaSH

STS

8 h

23.12 ± 1.46

51.43 ± 3.25 *

1.32 ± 0.11

53.06 ± 4.27 *

  1. The tables summarized the IC50 results of the studies shown in Fig. 8. Values are mean ± SEM, n = 4. One-way ANOVA was carried out to test significance. Note that there was a significant reduction in IC50 values of NaSH compared with those of STS
  2. *P < 0.01