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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Angiotensin-converting enzyme 2 activator diminazene aceturate prevents lipopolysaccharide-induced inflammation by inhibiting MAPK and NF-κB pathways in human retinal pigment epithelium

Fig. 5

Effect of ACE2-siRNA on the production of inflammatory cytokines in ARPE-19 cells and hRPE. IL-6, IL-8, and MCP-1 were detected by real-time PCR and ELISA assay in both ARPE-19 cells (a) and hRPE (b). DIZE reduced the expression of IL-6, IL-8, and MCP-1 in LPS-treated cells at both mRNA and protein levels, while ACE2-siRNA reversed this effect. All data are expressed as mean ± SEM (***p < 0.001, **p < 0.01, *p < 0.05, n = 4)

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Journal of Neuroinflammation

ISSN: 1742-2094