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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Angiotensin-converting enzyme 2 activator diminazene aceturate prevents lipopolysaccharide-induced inflammation by inhibiting MAPK and NF-κB pathways in human retinal pigment epithelium

Fig. 7

Effect of DIZE, A779, and ACE2-siRNA on the expression of Ang II and Ang-(1-7) in ARPE-19 cells and hRPE. The protein expression of Ang II and Ang-(1-7) was detected by ELISA assay in both ARPE-19 cells and hRPE. DIZE reduced the expression of Ang II in response to LPS, while A779 and ACE2-siRNA reversed this effect (a). DIZE increased the expression of Ang-(1-7) compared with LPS-treated cells, while A779 and ACE2-siRNA reversed this effect (b). All data are expressed as mean ± SEM (***p < 0.001, **p < 0.01, *p < 0.05, n = 4 ~ 6)

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Journal of Neuroinflammation

ISSN: 1742-2094