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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Angiotensin-converting enzyme 2 activator diminazene aceturate prevents lipopolysaccharide-induced inflammation by inhibiting MAPK and NF-κB pathways in human retinal pigment epithelium

Fig. 8

Effect of DIZE, A779, and ACE2-siRNA on the expression of AT1R and AT2R in ARPE-19 cells and hRPE. The mRNA level of AT1R and AT2R was detected by real-time PCR in both ARPE-19 cells and hRPE. DIZE reduced the expression of AT1R in response to LPS, while ACE2-siRNA reversed this effect. A779 did not affect the expression of AT1R. There was no significant difference of AT2R expression among each group in ARPE-19 cells (a) and hRPE (b). All data are expressed as mean ± SEM (***p < 0.001, **p < 0.01, *p < 0.05, n = 4)

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Journal of Neuroinflammation

ISSN: 1742-2094