Fig. 6
From: RGS10 deficiency ameliorates the severity of disease in experimental autoimmune encephalomyelitis
RGS10-null CD4+ T cells displayed attenuated migration to CXCL12, a ligand for CXCR4. CD4+ T cell migration to CXCL12 was tested in an in vitro transwell chemotaxis assay. a Histogram shows the levels of chemokine receptor CXCR4 staining on CD3+ CD19â CD4+ T lymphocytes from WT and RGS10-null mouse spleens, as determined by flow cytometry. b Percentage of CD4+ T cells from WT or RGS10 null mice (nâ=â3) that migrated to the lower chamber containing serum free-medium (VEH), CXCL12 (10Â nM) or under control conditions (CXCL12 in both lower and upper chambers) *, p < 0.05, two-way ANOVA