Fig. 7From: RGS10 deficiency ameliorates the severity of disease in experimental autoimmune encephalomyelitisRGS10-null Th1 but not Th17 cells adoptively transferred into WT mice conferred attenuated EAE. RGS10-null or WT mice (nâ=â6) were immunized with MOG35â55/CFA.. Nine days later, splenocytes and lymph node cells were harvested from RGS10-null and WT mice and then differentiated in vitro into Th1 cells or Th17 cells as described in the âMethodsâ section. Th1 or Th17 cells from RGS10-null or WT mice were injected into 5- to 6-week-old WT naĂŻve recipient mice; mice were followed clinically up to at least day 32. Mean clinical scores (±SEM) of RGS10 WT adoptive transfer recipients of encephalitogenic Th1 (a) or Th17 (b) cells from MOG35â55-immunized WT and RGS10-null donors. *pâ<â0.05, Mann-Whitney U testBack to article page