Skip to main content
Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Neuroinflammation and structural injury of the fetal ovine brain following intra-amniotic Candida albicans exposure

Fig. 5

Antenatal exposure to Candida albicans caused microglial (IBA-1) and astrocyte (GFAP) activation in the hippocampus. A significant increase (*p < 0.05) of the area fraction of IBA-1 (a–d) and GFAP (e–h) immunoreactivity (IR) was observed in all C. albicans-exposed animals compared to controls irrespective of fluconazole (F) treatment (a, e). No significant changes were found in the fluconazole-treated animals compared to controls. Representative figures show that the area fraction of the IBA-1 IR and GFAP IR was higher in the 3-day C. albicans group (c, g) and 5-day C. albicans-/fluconazole-treated group (d, h) compared to the control group (b, f). Images at ×20 magnification (inserts at ×200 magnification), scale bar = 100 μm

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094