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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures

Fig. 5

BAF312 induces an increase in iCa2+ levels in human astrocytes. Stimulation of human astrocytes with the S1P1/S1P5 receptor agonist BAF312 increases iCa2+ levels in Fluo-8 AM loaded human astrocytes. a Representative images taken from time-lapse series at baseline and after addition of BAF312 (30 s) is shown. All cells were stimulated and responded to 3 μM glutamate (150 s) (not shown). b Analysis showing traces of four separate experiments. c Average data showing BAF312 significantly promotes iCa2+ levels in human astrocytes, which is attenuated by the S1PR1-selective antagonist NIBR-0213 (n = 4)

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