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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Virus-mediated EpoR76E gene therapy preserves vision in a glaucoma model by modulating neuroinflammation and decreasing oxidative stress

Fig. 2

Treatment with rAAV.EpoR76E reduced the number, but not proliferation, of microglia in the retina. a, b Representative confocal micrographs of IBA-1 immunolabeling (green) of flat-mounted retinas from 8-month-old mice treated with rAAV.eGFP (a) or rAAV.EpoR76E (b). c, d Representative confocal micrographs of anti-IBA-1 (blue) and anti-Ki67 (green) double-labeling in retinal sections from 8-month-old mice treated with rAAV.eGFP (c) or rAAV.EpoR76E (d). e, f Box and whisker plots showing quantification of microglia number in the central (e) and peripheral (f) retinas. *p < 0.05, **p < 0.01, and ***p < 0.001. g Box and whisker plots of the percentage of anti-IBA-1-positive cells that were also anti-Ki67-positive. There was no statistically significant difference between rAAV.eGFP- and rAAV.EpoR76E-treated mice. h–j Representative fluorescein angiography in a normal retina (h) and glaucomatous retinas from mice treated with rAAV.eGFP (i) or rAAV.EpoR76E (j)

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Journal of Neuroinflammation

ISSN: 1742-2094