Skip to main content

Table 3 Binomial logistic regression models assessing the ability of inflammatory markers to predict poor patient outcome, controlling for injury severity

From: Inflammatory cytokine and chemokine profiles are associated with patient outcome and the hyperadrenergic state following acute brain injury

Marker Admission Hours after admission
6 12 24
OR P value OR P value OR P value OR P value
Unfavorable 6-month GOSE
 IL-1β 0.84 0.489 1.84* 0.002 1.65* 0.009 0.91 0.673
 IL-10 1.18 0.376 1.76* 0.005 1.57* 0.019 1.48* 0.034
 TNF-α 1.49* 0.024 1.61* 0.008 1.50* 0.021 1.30 0.138
 IL-8 1.66* 0.007 1.48* 0.030 1.44* 0.036 1.33 0.104
 MCP-1 1.42 0.052 1.09 0.603 1.24 0.213 1.39 0.067
 MDC 1.10 0.586 0.90 0.515 1.45 0.037* 0.85 0.363
Mortality         
 IL-1β 1.02 0.935 1.06 0.825 1.85* 0.038 1.15 0.598
 IL-10 1.19 0.417 2.82* <0.001 2.09* 0.003 2.20* 0.003*
 TNF-α 1.58* 0.027 1.77* 0.007 1.58* 0.033 1.19 0.395
 IL-8 1.31 0.168 1.89* 0.005 1.84 0.010* 1.37 0.176
 IP-10 3.11* <0.001 2.06* 0.002 1.59* 0.030 1.19 0.400
 MCP-1 1.26 0.230 1.46 0.069 1.57* 0.035 0.91 0.674
 MCP-4 1.43 0.090 1.49 0.065 0.99 0.964 0.57* 0.023
 MDC 1.03 0.864 0.91 0.620 1.14 0.529 0.71 0.114
 MIP-1β 1.13 0.544 1.27 0.243 1.29 0.221 0.89 0.592
 TARC 0.95 0.801 1.00 0.991 0.77 0.231 0.56* 0.015
 Eotaxin 1.90* 0.005 1.90* 0.007 1.33 0.208 0.79 0.304
  1. Models were controlled for admission GCS and AIS head scores
  2. All blood biomarker concentrations were standardized by quartiles. A one-unit increase is equivalent to a 25 % increase in biomarker concentration
  3. Abbreviations: OR odds ratio, GOSE extended Glasgow outcome scale, IL interleukin, TNF-α tumor necrosis factor-alpha, MCP monocyte chemoattractant protein, MDC macrophage-derived chemokine, IP-10 interferon-gamma induced protein-10, MIP-1β macrophage inflammatory protein–1β, TARC thymus and activation regulated chemokine
  4. *p < 0.05