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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Cocaine-mediated induction of microglial activation involves the ER stress-TLR2 axis

Fig. 6

Cocaine-mediated induction of phosphorylation-dependent TLR2 signaling pathway and microglial activation. a Cocaine-mediated induction of phosphorylation of TLR2 in BV2 cells. b Cocaine-mediated induction of NF-κB nuclear translocation in BV2 cells. c siRNA transfection was used to knock down Myd88. Myd88 siRNA but not si-Con inhibited cocaine-mediated induction of IL-6, MCP-1, and TNFα mRNAs, analyzed by qPCR using 18S rRNA as internal control. All data are presented as mean ± SD of three individual experiments. *p < 0.05, **p < 0.01, ***p < 0.01 vs control group (Student’s t test)

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