Fig. 5

Macrophage depletion improved neurological outcomes in mice following transient MCAO. a A series of cresyl violet stained coronal sections represented the brain atrophy in CLP, PBS, and Vehicle groups at 14 days after MCAO (a). Quantification of the brain atrophy volume is presented by the brain volume of contralateral subtracted ipsilateral hemisphere at 14 days after MCAO (b). Quantification of brain volume presented by ratio of ipsilateral/contralateral hemisphere brain volume at 14 days after MCAO (c). Data are mean ± SD, n = 7–8 per group. **p < 0.01, CLP vs. Vehicle or PBS. b Bar graph shows the mNSS assessment in CLP, PBS, and Vehicle groups at 1, 3, 7, and 14 days after MCAO. Data are mean ± SD, n = 5–8 per group. *p < 0.05, CLP vs. Vehicle or PBS. mNSS = modified neurological severity scores