Fig. 6
From: Macrophage depletion reduced brain injury following middle cerebral artery occlusion in mice
Macrophage depletion reduced myelin lesion. a Light brown boxes show the interested areas in the ipsilateral striatum (a). Photomicrographs show MBP-stained myelin in the peri-infarct region of the ischemic striatum in Vehicle (b), PBS (c), and CLP (d) groups at 14 days after MCAO. Scale bar = 100 μm. b Bar graph represents quantification of fold changes of mean IOD ratio (ipsilateral/contralateral hemisphere) in the CLP group compared to the PBS or Vehicle group. Data are mean ± SD, n = 4 per group. *p < 0.05, CLP vs. Vehicle or PBS. IOD = integrated optical density. c MBP expression in the ischemic striatum was determined by western blot. d Quantification of MBP expression by normalizing to the β-actin level in each group and set the Vehicle treated group as 1. Data are mean ± SD, n = 3 per group. *p < 0.05, CLP vs. Vehicle or PBS